Therapeutic applications of urease inhibitors
نویسندگان
چکیده
منابع مشابه
Urease inhibitors: A review
Urease inhibitors possess a wide application in agriculture, clinical science and understanding of enzyme kinetics. These inhibitors play a significant role in reducing the loss of nitrogen from urea fertilizer in the form of volatile ammonia and, thus, improve the utility of urea based fertilizers. Their impact as an effective drug against urease producing bacterial infection is well documente...
متن کاملTherapeutic applications of glycosidic carbonic anhydrase inhibitors.
The zinc enzymes carbonic anhydrases (CAs, EC 4.2.1.1) are very efficient catalysts for the reversible hydration of carbon dioxide to bicarbonate and hence play an important physiological role. In humans, 16 different isozymes have been described, some of them being involved in various pathological disorders. Several of these isozymes are considered as drug targets, and the design of selective ...
متن کاملTherapeutic applications of the carbonic anhydrase inhibitors
10.2217/14750708.4.3.355 © 2 Inhibitors of the zinc enzyme carbonic anhydrase (CA) targeting different isozymes among the 15 presently reported in humans have various therapeutic applications. These enzymes are efficient catalysts for the hydration of carbon dioxide to bicarbonate and protons, playing crucial physiological/pathological roles related to acid–base homeostasis, secretion of electr...
متن کاملN-substituted hydroxyureas as urease inhibitors.
In order to seek a urease inhibitor more potent than hydroxyurea (1), its alkyl- or phenyl-substituted derivatives were synthesized and evaluated for their effect on the jack bean urease. Of 16 compounds tested, m-methyl- (10) and m-methoxy-phenyl substituted hydroxyurea (13) showed the most potent inhibitory activities against the enzyme.
متن کاملPatho-Phyisology of Urease: Urease Inhibiters as a Significant Therapeutic Goal
Urease (urea amidohydrolase) is usually found in different bacteria, fungi, algae and plants. It is accountable for the hydrolysis of urea and thus, forming ammonia and carbamate, which is the final step of nitrogen metabolism in living organisms [1,2]. The carbamate intern quickly and spontaneously decomposes, yielding a second molecule of ammonia. These reactions may cause significant increas...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 1982
ISSN: 0305-7453,1460-2091
DOI: 10.1093/jac/10.3.159